KRP167
阳离子独立甘露糖-6-磷酸受体, Cation-independent mannose-6-phosphate receptor , CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, MPR 300, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor, M6P/IGF2 r
| Catalog Number | KRP167 |
| Alias | 阳离子独立甘露糖-6-磷酸受体, Cation-independent mannose-6-phosphate receptor , CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, MPR 300, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor, M6P/IGF2 r |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human IGF2R(43-1365 aa) |
| Molecular Name | IGF2R |
| Product Introduction | 阳离子独立甘露糖-6-磷酸受体调节细胞内甘露糖的转运，并参与生长因子的调控。。 |
| Molecular Weight | 160-180 kDa, |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | P11717 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | When Recombinant Human IGF-II R/IGF2R is immobilized at 2 μg/mL (100 µL/well), the concentration of Recombinant Human CREG Recombinant Human CREG that produces 50% of the optimal binding response is found to be approximately 2‑10 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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