| Catalog Number | KRP158 |
| Alias | 微管相关蛋白tau, Microtubule-associated protein tau , Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPTL, MTBT1, TAU, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human MAPT(1-441 aa) |
| Molecular Name | MAPT |
| Product Introduction | 微管相关蛋白tau参与神经退行性病变中的tau蛋白形成，影响神经功能。。 |
| Molecular Weight | 65-80 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | P10636-8 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | 联系销售经理获得最新活性数据 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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