Recombinant Human Neuromedin B Protein, N-His Tag
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产品编号
KRP140
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别名
神经肽B, Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B],
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP140 |
| Alias | 神经肽B, Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B], |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human NMB(25-121 aa) |
| Molecular Name | NMB |
| Product Introduction | 神经肽B神经肽，参与胃肠功能调节。。 |
| Molecular Weight | 15 kDa |
| Expression System | E. coli |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| Purification | Affinity Purification |
| Uniprot ID | P08949 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). {ECO:0000250|UniProtKB:P01297, ECO:0000250|UniProtKB:Q9CR53, ECO:0000269|PubMed:31601264}. |
| Endotoxin | ＜1.0EU/ug |
| Biological Activity | 联系销售经理获得最新活性数据 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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