Recombinant Human Neuromedin B Protein, N-His Tag_天津卡梅德科技发展有限公司

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Recombinant Human Neuromedin B Protein, N-His Tag

Recombinant Human Neuromedin B Protein, N-His Tag

产品编号

KRP140

别名

神经肽B, Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B],

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Alias	神经肽B, Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B],
Catalog Number	KRP140
Molecular Name	NMB
Molecular Weight	15 kDa
Size	20ug, 50ug, 100ug, 200ug, 1mg
Concentration	联系销售经理获得最新批次的浓度
Purity	≥90%
Product Description	Human NMB(25-121 aa)
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	＜1.0EU/ug
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). {ECO:0000250\|UniProtKB:P01297, ECO:0000250\|UniProtKB:Q9CR53, ECO:0000269\|PubMed:31601264}.
Species	Human
Purification	Affinity Purification
Endotoxin	Supplied in PBS
Biological Activity	联系销售经理获得最新活性数据
Uniprot ID	P08949
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Display Peptides	E. coli

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