| Catalog Number | KRP101 |
| Alias | 白细胞介素-5（IL-5）, Interleukin-5 , IL-5, B-cell growth factor II, BCGF-II, Cytotoxic T-lymphocyte inducer, Eosinophil differentiation factor, T-cell replacing factor, TRF, Il-5, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Il5(21-133 aa) |
| Molecular Name | Il5 |
| Product Introduction | 白细胞介素-5（IL-5）促进B细胞生长的细胞因子。。 |
| Molecular Weight | 18-25 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥97% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | P04401 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:10444455, PubMed:1873482). Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (PubMed:3128631). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity). {ECO:0000250|UniProtKB:P05113, ECO:0000269|PubMed:10444455, ECO:0000269|PubMed:1873482, ECO:0000269|PubMed:3128631}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Recombinant Mouse IL-5 stimulates cell proliferation of the TF-1 Mouse erythroleukemic cells. The ED50 forthis effect is 0.15-0.5ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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