| Catalog Number | KRP084 |
| Alias | 白介素-3, Interleukin-3 , IL-3, Hematopoietic growth factor, Mast cell growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor, Csfmu, Il-3, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Il3(1-166 aa) |
| Molecular Name | Il3 |
| Product Introduction | 白介素-3细胞表面糖蛋白，参与免疫识别。。 |
| Molecular Weight | 10-35 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥92% |
| Purification | Affinity Purification |
| Uniprot ID | P01586 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (By similarity). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (PubMed:10376805, PubMed:31990690, PubMed:8378315). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (By similarity). {ECO:0000250|UniProtKB:P08700, ECO:0000269|PubMed:10376805, ECO:0000269|PubMed:31990690, ECO:0000269|PubMed:8378315, ECO:0000269|PubMed:9446636}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured in a cell proliferation assay using BaF3 mouse pro-B cells. The ED50 forthis effect is 1.5-6 pg/mL, corresponding to a specific activity of 1.67 × 108~6.67× 108 units/mg. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
在运输过程中，应使用干冰或冷链运输，并确保蛋白在运输过程中维持适当的低温。
可以使用BCA法、Bradford法或紫外吸光度法来测量蛋白的浓度。
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