Recombinant Mouse IFN-beta Protein, C-His Tag_天津卡梅德科技发展有限公司

Recombinant Mouse IFN-beta Protein, C-His Tag

产品编号

KRP080

别名

干扰素β, Interferon beta , IFN-beta, Ifb, Ifnb,

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Catalog Number	KRP080
Alias	干扰素β, Interferon beta , IFN-beta, Ifb, Ifnb,
Size	20ug, 50ug, 100ug, 200ug, 1mg
Product Description	Mouse Ifnb1(22-182 aa)
Molecular Name	Ifnb1
Product Introduction	干扰素β调控造血细胞增殖和分化的重要因子。。
Molecular Weight	30 kDa
Expression System	HEK293F Cells
Species	Mouse
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P01575
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	Supplied in PBS
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10708458, PubMed:23872679). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (PubMed:23872679). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (PubMed:10708458, PubMed:14597717). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (PubMed:26451483). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (PubMed:14597717). {ECO:0000250\|UniProtKB:P01574, ECO:0000269\|PubMed:10708458, ECO:0000269\|PubMed:14597717, ECO:0000269\|PubMed:23872679, ECO:0000269\|PubMed:26451483}.
Endotoxin	< 0.1 EU per ug
Biological Activity	Recombinant Mouse IFN-beta enhances STAT1 autophosphorylation in Bone-marrow derived macrophage (BMDM). 5-500 ng/mL of Recombinant Mouse IFN-beta can enhance STAT1 autophosphorylation.
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。