Recombinant Human Netrin 1 Protein, C-His Tag
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产品编号
KRP061
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别名
Netrin-1, Netrin-1 , Epididymis tissue protein Li 131P, NTN1L,
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP061 |
| Alias | Netrin-1, Netrin-1 , Epididymis tissue protein Li 131P, NTN1L, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human NTN1(22-604 aa) |
| Molecular Name | NTN1 |
| Product Introduction | Netrin-1参与抑制癌细胞生长的蛋白质。。 |
| Molecular Weight | 80-85 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | O95631 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335). {ECO:0000269|PubMed:15343335, ECO:0000269|PubMed:28483977}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its binding ability in a functional ELISA. When Recombinant Rat UNC5H2 Fc Chimera is immobilized at 5 μg/mL, Recombinant Human Netrin- 1 binds with an apparent Kd <1 nM. Measured in a cell proliferation assay using RT4‑D6P2T rat schwannoma cel |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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