Recombinant Mouse Neuropilin 1 Protein, C-His Tag
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产品编号
KRP031
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别名
神经引导蛋白-1, Neuropilin-1 , A5 protein, CD antigen CD304, Nrp,
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Alias | 神经引导蛋白-1, Neuropilin-1 , A5 protein, CD antigen CD304, Nrp, |
| Catalog Number | KRP031 |
| Molecular Name | Nrp1 |
| Molecular Weight | 100-120 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Product Description | Mouse Nrp1(22-856 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed:26503042). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity). Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity). {ECO:0000250|UniProtKB:O14786, ECO:0000269|PubMed:26503042}. |
| Species | Mouse |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse Neuropilin‑1 can bind recombinant human VEGF165 with an apparent KD <1 nM. |
| Uniprot ID | P97333 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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