Recombinant Mouse Klotho Protein, C-His Tag
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产品编号
KRP030
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别名
克洛索蛋白, Klotho , EC 3.2.1.31,
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP030 |
| Alias | 克洛索蛋白, Klotho , EC 3.2.1.31, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Kl(Ala35-Lys982) |
| Molecular Name | Kl |
| Product Introduction | 克洛索蛋白参与内分泌功能调节并调节细胞的存活与增殖。 |
| Molecular Weight | 125-130 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| Purification | Affinity Purification |
| Uniprot ID | O35082-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.; The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with human FGF RIIIc. The ED50 forthis effect is 0.04- 0.4 µg/mL in the presence of 1 µg/mL of Recombinant Human FGF‑23 and 10 µg/mL of heparin. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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