| Catalog Number | KRP024 |
| Alias | 肿瘤坏死因子受体超家族成员11B, Tumor necrosis factor receptor superfamily member 11B , Osteoclastogenesis inhibitory factor, Osteoprotegerin, Ocif, Opg, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Tnfrsf11b(Glu22-Leu401(Arg138GIn)) |
| Molecular Name | Tnfrsf11b |
| Product Introduction | 肿瘤坏死因子受体超家族成员11B参与神经系统的发育及免疫细胞的调节。 |
| Molecular Weight | 85-95 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | O08712 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:10952716}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L‑929 mouse fibroblast cells treated with TRAIL. The ED50 forthis effect is 3-15 ng/mL in the presence of 12 ng/mL of cross-linked Recombinant Human TRAIL/TNFSF10. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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