Mouse CD279 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse CD279 Protein, His Tag

Mouse CD279 Protein, His Tag

产品编号

KMP2367

别名

程序性死亡分子, Programmed cell death protein 1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	程序性死亡分子, Programmed cell death protein 1
Catalog Number	KMP2367
Product Description	The Mouse CD279 Protein(KMP2367) is produced in HEK293 Cells and the target gene encoding Leu25-Gln167 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD279
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 150mM NaCl, pH8.0
Background	Programmed Death-1(PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif(ITIM) and an immunoreceptor tyrosine-based switch motif(ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1(PD-1) with its ligands, programmed death ligand B7H1(PD-L1) and B7DC(PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.
SDS-PAGE
Predicted Molecular Weight	16.15 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q02242
References	1.Immunity 11:141-151 (1999) 2.J. Exp. Med. 192:1027-1034 (2000) 3.Science 291:319-322 (2001) 4.Nat. Immunol. 2:261-268 (2001) 5.Proc. Natl. Acad. Sci. U.S.A. 98:13866-13871 (2001) 6.Proc. Natl. Acad. Sci. U.S.A. 105:3011-3016 (2008) 7.Proc. Natl. Acad. Sci. U.S.A. 105:10483-10488 (2008) 8.J. Exp. Med. 208:395-407 (2011) 9.J. Exp. Med. 209:1201-1217 (2012)
Function	Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:10485649, PubMed:11698646, PubMed:11209085, PubMed:21300912). Delivers inhibitory signals upon binding to ligands, such as CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:11015443, PubMed:11224527, PubMed:22641383, PubMed:18287011, PubMed:18641123). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed:22641383). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (PubMed:11698646, PubMed:22641383). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (By similarity).

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