Mouse CD278 Protein, His Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Mouse CD278 Protein, His Tag

Mouse CD278 Protein, His Tag

产品编号

KMP2314

别名

诱导性 T 细胞成本刺激器, Inducible T-cell costimulator, CD278

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	诱导性 T 细胞成本刺激器, Inducible T-cell costimulator, CD278
Catalog Number	KMP2314
Product Description	The Mouse CD278 Protein(KMP2314) is produced in HEK293 Cells and the target gene encoding Glu21-Leu142 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD278
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Inducible Costimulator(ICOS) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA4 and PD1. ICOS shares approximately 39% amino acid similarity with CD 28 and CTLA4. Mouse and human ICOS share approximately 72% amino acid identity. ICOS is expressed on most CD45RO+ cells. ICOS expression is up-regulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. In addition, ICOS is more potent in the induction of IL-10 production, acytokine important for suppressive function of T regulatory cells.
SDS-PAGE
Predicted Molecular Weight	14.72 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q9WVS0#function
References	1.Nature 402:827-832 (1999) 2.Nature 409:102-105 (2001) 3.Nature 409:105-109 (2001)
Function	Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0