Human CD274 Protein, Fc Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human CD274 Protein, Fc Tag, Avi Tag

Human CD274 Protein, Fc Tag, Avi Tag

产品编号

KMP2304

别名

程序性死亡蛋白配体-1, programmed cell death 1 ligand 1, CD274

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	程序性死亡蛋白配体-1, programmed cell death 1 ligand 1, CD274
Catalog Number	KMP2304
Product Description	The Human CD274 Protein(KMP2304) is produced in HEK293 Cells and the target gene encoding Phe19-Thr239 is expressed with a Fc, Avi tag at the C-terminus.
Molecular Name	CD274
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 150mM NaCl, pH7.4
Background	CD274, also known as B7-H1 or programmed death ligand 1(PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1(PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
SDS-PAGE
Predicted Molecular Weight	25.3 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q9NZQ7
References	1.Nat. Med. 5:1365-1369 (1999) 2.J. Exp. Med. 192:1027-1034 (2000) 3.Nature 549:106-110 (2017) 4.Nature 549:101-105 (2017) 5.Nature 549:106-110 (2017) 6.Nature 549:101-105 (2017)
Function	1.Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) . 2.The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival . The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.

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