Human CD30 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human CD30 Protein, His Tag, Avi Tag

Human CD30 Protein, His Tag, Avi Tag

产品编号

KMP2273

别名

肿瘤坏死因子受体8, Tumor necrosis factor receptor superfamily member 8, CD30

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2273
Alias	肿瘤坏死因子受体8, Tumor necrosis factor receptor superfamily member 8, CD30
Size	50ug, 100ug, 200ug
Product Description	The Human CD30 Protein(KMP2273) is produced in HEK293 Cells and the target gene encoding Phe19-Lys379 is expressed with a 6His, Avi tag at the C-terminus.
Molecular Name	CD30
Product Introduction	CD30：TNF受体超家族成员，通过跨膜形式参与淋巴细胞活化和信号传导。
Molecular Weight	39.25 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P28908
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	20mM PB, 150mM NaCl, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L(CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma(ALCL) and classical Hodgkin lymphoma(cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。
重组蛋白纯化常用的方法有哪些？

常用的纯化方法包括亲和层析（如His-Tag、GST-Tag）、离子交换层析、疏水相互作用层析（HIC）和凝胶过滤层析。具体方法取决于蛋白特性和标签类型。

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