Human CD326 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human CD326 Protein, His Tag, Avi Tag

Human CD326 Protein, His Tag, Avi Tag

产品编号

KMP2272

别名

上皮细胞粘附分子, Epithelial Cell Adhesion Molecule, CD326

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	上皮细胞粘附分子, Epithelial Cell Adhesion Molecule, CD326
Catalog Number	KMP2272
Product Description	The Human CD326 Protein(KMP2272) is produced in HEK293 Cells and the target gene encoding Gln24-Lys265 is expressed with a 6His, Avi tag at the C-terminus.
Molecular Name	CD326
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 150mM NaCl, pH7.2
Background	Epithelial Cell Adhesion Molecule(EpCAM) is a signal type I transmembrane glycoprotein that belongs to the EPCAM family. EpCAM is composed of an extracellular domain with one thyroglobulin type-1 domain, a transmembrane domain and a cytoplasmic domain. EpCAM is found on the surface of adenocarcinoma, but not on mesodermal or neural cell membranes. The EpCAM molecule has been shown to function as a homophilic Ca2+ independent adhesion molecule. It may act as a physical homophilic interaction molecule between intestinal epithelial cells(IECs) and intraepithelial lymphocytes(IELs) at the mucosal epithelium as an immunological barrier providing the first line of defense against infection. Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8(HNPCC8) and diarrhea type 5(DIAR5). EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells.
SDS-PAGE
Predicted Molecular Weight	28.25 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	P16422
References	1.Oncogene 23:5748-5758 (2004) 2.Cancer Lett. 225:151-157 (2005) 3.Stem Cells 28:29-35 (2010) 4.J. Biol. Chem. 285:8719-8732 (2010)
Function	May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

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