KRP076
Kininogen-1, Kininogen-1 , Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight kininogen, HMWK, Williams-Fitzgerald-Flaujeac factor, [Cleaved into: Kininogen-1 heavy chain; T-kinin , Ile-Ser-Bradykinin, ; Bradykinin , Kallidin I,
| Catalog Number | KRP076 |
| Alias | Kininogen-1, Kininogen-1 , Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight kininogen, HMWK, Williams-Fitzgerald-Flaujeac factor, [Cleaved into: Kininogen-1 heavy chain; T-kinin , Ile-Ser-Bradykinin, ; Bradykinin , Kallidin I, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human KNG1(19-644 aa) |
| Molecular Name | KNG1 |
| Product Introduction | Kininogen-1干扰病毒感染的免疫因子，调节免疫应答。。 |
| Molecular Weight | 120 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | P01042-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). {ECO:0000305|PubMed:4322742, ECO:0000305|PubMed:6055465}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR- AMC. The IC50 value is < 3 nM, as measured under the described conditions. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
销售微信
官方公众号
0
