Human CD137L Protein, Fc Tag_天津卡梅德科技发展有限公司

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Human CD137L Protein, Fc Tag

Human CD137L Protein, Fc Tag

产品编号

KMP2418

别名

肿瘤坏死因子配体超家族成员 9, CD137L, TNFSF9

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2418
Alias	肿瘤坏死因子配体超家族成员 9, CD137L, TNFSF9
Size	50ug, 100ug, 200ug
Product Description	The Human CD137L Protein(KMP2418) is produced in HEK293 Cells and the target gene encoding Arg71-Glu254 is expressed with a Fc tag at the N-terminus.
Molecular Name	CD137L
Product Introduction	CD137L（4-1BBL）：CD137的天然配体，通过跨膜形式参与免疫细胞活化和功能调节。
Molecular Weight	20.24 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>90%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	A0A0U5J8I0
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death(AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何避免重组蛋白降解？

可在纯化过程中加入蛋白酶抑制剂、低温操作，优化储存条件（如分装冻存于-80°C），并避免反复冻融。某些情况下，可选用蛋白酶缺陷型宿主菌减少降解风险。
如何检测重组蛋白的表达和纯度？

常用SDS-PAGE、Western Blot检测表达，BCA/Bradford法测浓度，HPLC或质谱分析纯度，生物活性实验（如ELISA、酶活检测）验证功能。

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