Mouse INDO Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse INDO Protein, His Tag

Mouse INDO Protein, His Tag

产品编号

KMP2318

别名

吲哚 2, 3-二氧合酶 , Indole 2, 3-dioxygenase, INDO

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2318
Alias	吲哚 2, 3-二氧合酶 , Indole 2, 3-dioxygenase, INDO
Size	50ug, 100ug, 200ug
Product Description	The Mouse INDO Protein(KMP2318) is produced in E.coli and the target gene encoding Met1-Pro407 is expressed with a 6His tag at the N-terminus.
Molecular Name	INDO
Product Introduction	INDO（IDO1）：色氨酸代谢限速酶，催化色氨酸沿犬尿氨酸途径的降解反应。
Molecular Weight	46.47 kDa
Expression System	E. coli
Species	Mouse
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P28776
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	20mM Sodium Acetate, 150mM NaCl and 20% Glycerol, pH4.5
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Indoleamine 2,3-dioxygenase(IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。
重组蛋白纯化常用的方法有哪些？

常用的纯化方法包括亲和层析（如His-Tag、GST-Tag）、离子交换层析、疏水相互作用层析（HIC）和凝胶过滤层析。具体方法取决于蛋白特性和标签类型。

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