| Catalog Number | KMPH783 |
| Alias | 真核翻译起始因子 2α 激酶 3；EIF2AK3; HsPEK; PERK; PEK; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; Eukaryotic translation initiation factor 2-alpha kinase 3 |
| Size | 100ug |
| Product Description | The Recombinant Human EIF2AK3 Protein with His Tag (KMPH783) is expressed from E.coli. It contains 593-1077 AA. |
| Molecular Name | EIF2AK3 |
| Expression System | E.coli |
| Species | Human |
| Concentration | Batch to Batch |
| Purity | > 90% as determined by SDS-PAGE |
| Purification | Affinity Purification |
| Storage Condition | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | As an endoplasmic reticulum (ER)-resident type I transmembrane kinase, this protein (EIF2AK3/PERK) is activated by ER stress and phosphorylates the alpha subunit of eIF2, leading to a rapid suppression of global protein synthesis. This process is a core component of the unfolded protein response (UPR), which mitigates stress caused by misfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome, an autosomal recessive disorder characterized by infantile-onset diabetes and skeletal dysplasia. |
| Predicted Molecular Weight | 57.32 kDa |
| Tag | N-His Tag |
| Reconstitution | Reconstitute in sterile water for a stock solution. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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