Pneumococcal Type V Antigen, CRM197-Conjugate_天津卡梅德科技发展有限公司

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Pneumococcal Type V Antigen, CRM197-Conjugate

Pneumococcal Type V Antigen, CRM197-Conjugate

产品编号

BAG1134

别名

CRM197结合5型肺炎球菌抗原,CRM197结合肺炎球菌抗原, 肺炎球菌, Pneumococcal Type V, CRM197

规格

250ul
1ml

DATASHEET MSDS

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产品介绍

Catalog Number	BAG1134
Alias	CRM197结合5型肺炎球菌抗原,CRM197结合肺炎球菌抗原, 肺炎球菌, Pneumococcal Type V, CRM197
Size	250ul, 1ml
Molecular Name	Pneumococcal
Expression System	Pneumococcal
Species	Bacteria
Purity	>95%
Purification	IEC & HPLC
Storage Condition	Store the lyophilized powder at 4℃ for 6 months. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Formulation	Powder or 0.1M PBS, PH 7.0
Background	The symptoms of pneumococcal pneumonia can occur suddenly, typically presenting as a severe chill, later including a severe fever, cough, shortness of breath, rapid breathing, and chest pains. Other symptoms like nausea, vomiting, headache, fatigue, and muscle aches could also accompany the original symptoms. Sometimes the coughing can produce rusty or blood-streaked sputum. In 25% of cases, a parapneumonic effusion may occur. Chest X-rays will typically show lobar consolidation or patchy infiltrates.
Application	Immunogen, WB, ELISA

FAQ

CRM197结合型抗原的制备流程是怎样的？

这是一个高度复杂和精密的生物化学过程，主要步骤包括： CRM197蛋白生产：通过基因工程菌（如Corynebacterium diphtheriae 或重组E. coli）发酵生产，并经过多步纯化得到高纯度CRM197蛋白。多糖活化：对特定血清型的肺炎球菌荚膜多糖进行化学修饰（例如，使用氰化溴、CDAP或高碘酸钠等），在其链上引入活性基团（如氰酸酯、醛基）。连接（结合）：将活化的多糖与CRM197蛋白上的氨基（通常是赖氨酸残基的ε-氨基）在控制条件下进行化学反应，形成稳定的共价键。纯化与鉴定：对结合产物进行纯化，去除未反应的多糖和蛋白，并通过多种分析技术（如SEC-HPLC、SDS-PAGE、免疫学方法等）确定结合率、分子大小、游离多糖含量等关键质量属性。

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