Recombinant Mouse IFN-beta Protein, C-Fc and His
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产品编号
KRP667
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别名
干扰素β, Interferon beta , IFN-beta, Ifb, Ifnb, Interferon beta
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP667 |
| Alias | 干扰素β, Interferon beta , IFN-beta, Ifb, Ifnb, Interferon beta |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Ifnb1(Ile 22 -Asn 182) |
| Molecular Name | Ifnb1 |
| Product Introduction | 干扰素β具有抗病毒作用，调节免疫反应，常用于多发性硬化症治疗。。 |
| Molecular Weight | 60 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | P01575 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10708458, PubMed:23872679). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (PubMed:23872679). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (PubMed:10708458, PubMed:14597717). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (PubMed:26451483). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (PubMed:14597717). {ECO:0000250|UniProtKB:P01574, ECO:0000269|PubMed:10708458, ECO:0000269|PubMed:14597717, ECO:0000269|PubMed:23872679, ECO:0000269|PubMed:26451483}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Immobilized Recombinant Mouse IFNAR2 at 2 μg/mL (100 μL/well) can bind Biotinylated Recombinant Mouse IFN-beta. The ED50 for this effect is 4.314 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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