| Catalog Number | KRP665 |
| Alias | 可诱导的T细胞共刺激因子, Inducible T-cell costimulator , Activation-inducible lymphocyte immunomediatory molecule, CD antigen CD278, AILIM, Inducible T-cell costimulator |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human ICOS(Glu21-Phe141) |
| Molecular Name | ICOS |
| Product Introduction | 可诱导的T细胞共刺激因子通过共刺激信号增强T细胞活性，参与免疫应答。。 |
| Molecular Weight | 50-60 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | Q9Y6W8, NM_012092.3 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response (PubMed:9930702). Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells (PubMed:33033255). Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (PubMed:27135603). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (By similarity). In addition, activates PI3K signaling pathways independently of calcium flux (PubMed:30523347). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250|UniProtKB:Q9WVS0, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:30523347, ECO:0000269|PubMed:33033255, ECO:0000269|PubMed:9930702}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Immobilized human B7-H2/ICOSLG at 1 μg/mL (100 μL/well) can bind Human ICOS/CD278 with a linear range of 2-14.8 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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