| Catalog Number | KRP611 |
| Alias | 唾液酸结合Ig样凝集素8, Sialic acid-binding Ig-like lectin 8 , Siglec-8, Sialoadhesin family member 2, SAF-2, SAF2, Sialic acid-binding Ig-like lectin 8 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human SIGLEC8(17-363 aa) |
| Molecular Name | SIGLEC8 |
| Product Introduction | 唾液酸结合Ig样凝集素8通过与糖分子结合调节免疫反应。。 |
| Molecular Weight | 45-60 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q9NYZ4-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells (PubMed:10625619, PubMed:10856141). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658). {ECO:0000269|PubMed:10625619, ECO:0000269|PubMed:10856141, ECO:0000269|PubMed:27357658}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its binding ability in a functional ELISA. When Biotinylated Sialyl Lewis X was immobilized at 0.05 μg/mL (100 μL/well), it binds Recombinant Human Siglec- 8. The concentration of Human Siglec-8 that produces 50% of the optimal binding respons |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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