| Catalog Number | KRP585 |
| Alias | 白细胞介素-1受体样2, Interleukin-1 receptor-like 2 , EC 3.2.2.6, IL-36 receptor, IL-36R, Interleukin-1 receptor-related protein 2, IL-1Rrp2, IL1R-rp2, IL1RRP2, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human IL1RL2(20-335 aa) |
| Molecular Name | IL1RL2 |
| Product Introduction | 白细胞介素-1受体样2调节免疫反应，参与多种炎症性疾病的发生。。 |
| Molecular Weight | 80-90 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q9HB29 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7, ECO:0000269|PubMed:11466363}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Immobilized Human IL-36 beta /IL-1F8 at 2 µg/mL (100 µL/well), Biotinylated Recombinant Human IL-1Rrp2/IL-1R6 Fc Chimera Avitag binds with an ED50 of 1.50-15.0 μg/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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