Recombinant Human Siglec-1 Protein, C-His Tag_天津卡梅德科技发展有限公司

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Recombinant Human Siglec-1 Protein, C-His Tag

Recombinant Human Siglec-1 Protein, C-His Tag

产品编号

KRP569

别名

半乳糖凝集素4C, Sialoadhesin , Sialic acid-binding Ig-like lectin 1, Siglec-1, CD antigen CD169, SN,

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Alias	半乳糖凝集素4C, Sialoadhesin , Sialic acid-binding Ig-like lectin 1, Siglec-1, CD antigen CD169, SN,
Catalog Number	KRP569
Molecular Name	SIGLEC1
Molecular Weight	175-190 kDa
Size	20ug, 50ug, 100ug, 200ug, 1mg
Concentration	联系销售经理获得最新批次的浓度
Purity	≥90%
Product Description	Human SIGLEC1(20-1641 aa)
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	< 0.1 EU per ug
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed:12940982, PubMed:33489013). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed:28129379). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 (PubMed:28129379, PubMed:34782760). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (PubMed:12940982). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (PubMed:26358190). {ECO:0000250\|UniProtKB:Q62230, ECO:0000269\|PubMed:12940982, ECO:0000269\|PubMed:26358190, ECO:0000269\|PubMed:28129379, ECO:0000269\|PubMed:33489013, ECO:0000269\|PubMed:34782760}.; (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane. {ECO:0000269\|PubMed:31160823}.
Species	Human
Purification	Affinity Purification
Endotoxin	Supplied in PBS
Biological Activity	Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. The ED50 forthis effect is 0.6‑3 µg/mL
Uniprot ID	Q9BZZ2-1
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Display Peptides	HEK293F Cells

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