KRP561
连接粘附分子C, Junctional adhesion molecule C , JAM-C, JAM-2, Junctional adhesion molecule 3, JAM-3, [Cleaved into: Soluble form of JAM-C , sJAM-C, ], UNQ859/PRO1868, Junctional adhesion molecule C
| Catalog Number | KRP561 |
| Alias | 连接粘附分子C, Junctional adhesion molecule C , JAM-C, JAM-2, Junctional adhesion molecule 3, JAM-3, [Cleaved into: Soluble form of JAM-C , sJAM-C, ], UNQ859/PRO1868, Junctional adhesion molecule C |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human JAM3(32-241 aa) |
| Molecular Name | JAM3 |
| Product Introduction | 连接粘附分子C调节细胞间粘附和免疫反应。。 |
| Molecular Weight | 60-65 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q9BX67 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity). {ECO:0000250|UniProtKB:A3KPA0, ECO:0000250|UniProtKB:Q9D8B7, ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11823489, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:23255084, ECO:0000269|PubMed:24357068, ECO:0000305|PubMed:28196865}.; [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. {ECO:0000269|PubMed:20592283}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to inhibit the adhesion of J45.01 human acute lymphoblastic leukemia T lymphocytes on immobilized JAM- 2 (VE-JAM)/Fc Chimera. When 0.2 µg/mL (100 µL/well) of rhJAM-B/Fc Chimera is immobilized on goat anti-human IgG Fc Chimera antib |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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