KRP255
白细胞介素-3受体亚单位alpha, Interleukin-3 receptor subunit alpha , IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, CD antigen CD123, IL3R, Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha,
| Catalog Number | KRP255 |
| Alias | 白细胞介素-3受体亚单位alpha, Interleukin-3 receptor subunit alpha , IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, CD antigen CD123, IL3R, Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human IL3RA(20-305 aa) |
| Molecular Name | IL3RA |
| Product Introduction | 白细胞介素-3受体亚单位alpha通过结合IL-3，调节免疫细胞的增殖与分化。。 |
| Molecular Weight | 45-60 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | P26951-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). {ECO:0000250|UniProtKB:P26952, ECO:0000269|PubMed:10527461, ECO:0000269|PubMed:29374162}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Immobilized recombinant Human IL3 at 4 μg/mL (100 μL/well) can bind recombinant Human IL3RA, the EC50 of Human IL3RA is 5.3 μg/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
销售微信
官方公众号
0
