| Catalog Number | KRP116 |
| Alias | 补体C2, Complement C2 , C3/C5 convertase, [Cleaved into: Complement C2a; Serine protease complement C2b , EC 3.4.21.43, ], |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human C2(21-752 aa) |
| Molecular Name | C2 |
| Product Introduction | 补体C2补体系统中的关键蛋白，促进免疫反应。。 |
| Molecular Weight | 103 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | P06681 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12878586, PubMed:17027507, PubMed:18204047, PubMed:39914456). Component C2 is part of the classical, lectin and GZMK complement systems (PubMed:12878586, PubMed:17027507, PubMed:18204047, PubMed:39914456). {ECO:0000269|PubMed:12878586, ECO:0000269|PubMed:17027507, ECO:0000269|PubMed:18204047, ECO:0000269|PubMed:39914456}.; [Serine protease complement C2b]: Catalytic component of the complement C3 and C5 convertase complexes (PubMed:12878586, PubMed:17027507, PubMed:18204047, PubMed:6906228). Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase (PubMed:6611150, PubMed:6906228). As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways (PubMed:14561755, PubMed:17027507). As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex (PubMed:12878586, PubMed:17027507, PubMed:18204047). {ECO:0000269|PubMed:12878586, ECO:0000269|PubMed:14561755, ECO:0000269|PubMed:17027507, ECO:0000269|PubMed:18204047, ECO:0000269|PubMed:6611150, ECO:0000269|PubMed:6906228}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to cleave a colorimetric peptide substrate, N- carbobenzyloxyGly-ArgThioBenzyl ester (Z-GR-SBzl), in the presence of 5,5’Dithio-bis (2- nitrobenzoic acid) (DTNB). The specific activity is >35 pmol/min/µg, as measured underthe descr |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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