Recombinant Human Siglec-1 Protein, C-His Tag
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产品编号
KRP569
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别名
半乳糖凝集素4C, Sialoadhesin , Sialic acid-binding Ig-like lectin 1, Siglec-1, CD antigen CD169, SN,
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP569 |
| Alias | 半乳糖凝集素4C, Sialoadhesin , Sialic acid-binding Ig-like lectin 1, Siglec-1, CD antigen CD169, SN, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human SIGLEC1(20-1641 aa) |
| Molecular Name | SIGLEC1 |
| Product Introduction | 半乳糖凝集素4C在神经发育、免疫应答中起重要作用。。 |
| Molecular Weight | 175-190 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| Purification | Affinity Purification |
| Uniprot ID | Q9BZZ2-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed:12940982, PubMed:33489013). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed:28129379). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 (PubMed:28129379, PubMed:34782760). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (PubMed:12940982). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (PubMed:26358190). {ECO:0000250|UniProtKB:Q62230, ECO:0000269|PubMed:12940982, ECO:0000269|PubMed:26358190, ECO:0000269|PubMed:28129379, ECO:0000269|PubMed:33489013, ECO:0000269|PubMed:34782760}.; (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane. {ECO:0000269|PubMed:31160823}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. The ED50 forthis effect is 0.6‑3 µg/mL |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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