Rabbit Anti-MFSD8 Polyclonal Antibody
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产品编号
PAV2304
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别名
major facilitator superfamily domain containing 8, CCMD, CLN7, SLC74A1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | major facilitator superfamily domain containing 8, CCMD, CLN7, SLC74A1 |
| Catalog Number | PAV2304 |
| Product Description | Rabbit polyclonal antibody raised against human MFSD8 (Major facilitator superfamily domain-containing protein 8). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MFSD8 |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转运蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008] |
| Immunogen | This antibody was raised against from part region of human MFSD8 protein (UniProt: Q8NHS3) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 256471 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈57.6 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 57.6 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q8NHS3 |
| Note | Gene ID: 256471; UniProt: Q8NHS3; Chromosome: 4q28.2; Predicted MW: 57.6 kDa |
| Function | Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MFSD8 Polyclonal Antibody |
| Target | MFSD8 |
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