Rabbit Anti-POLK Polyclonal Antibody
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产品编号
PAV3110
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别名
DNA polymerase kappa, DINB1, DINP, POLQ
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | DNA polymerase kappa, DINB1, DINP, POLQ |
| Catalog Number | PAV3110 |
| Product Description | Rabbit polyclonal antibody raised against human POLK (DNA polymerase kappa). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | POLK |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录与RNA加工 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016] |
| Immunogen | This antibody was raised against from part region of human POLK protein (UniProt: Q9UBT6) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 51426 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈98.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 98.8 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9UBT6 |
| Note | Gene ID: 51426; UniProt: Q9UBT6; Chromosome: 5q13.3; Predicted MW: 98.8 kDa |
| Function | DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human POLK Polyclonal Antibody |
| Target | POLK |
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