Rabbit Anti-SGPL1 Polyclonal Antibody
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产品编号
PAV3652
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别名
sphingosine-1-phosphate lyase 1, NPHS14, RENI, S1PL, SPL
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sphingosine-1-phosphate lyase 1, NPHS14, RENI, S1PL, SPL |
| Catalog Number | PAV3652 |
| Product Description | Rabbit polyclonal antibody raised against human SGPL1 (Sphingosine-1-phosphate lyase 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SGPL1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 代谢酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables sphinganine-1-phosphate aldolase activity. Involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum. Implicated in RENI syndrome. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human SGPL1 protein (UniProt: O95470) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 8879 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈63.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 63.5 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | O95470 |
| Note | Gene ID: 8879; UniProt: O95470; Chromosome: 10q22.1; Predicted MW: 63.5 kDa |
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SGPL1 Polyclonal Antibody |
| Target | SGPL1 |
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