Rabbit Anti-PCSK6 Polyclonal Antibody
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产品编号
PAV2972
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别名
proprotein convertase subtilisin/kexin type 6, PACE4, SPC4
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | proprotein convertase subtilisin/kexin type 6, PACE4, SPC4 |
| Catalog Number | PAV2972 |
| Product Description | Rabbit polyclonal antibody raised against human PCSK6 (Proprotein convertase subtilisin/kexin type 6). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PCSK6 |
| Species | Human, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 蛋白酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014] |
| Immunogen | This antibody was raised against from part region of human PCSK6 protein (UniProt: P29122) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 5046 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat |
| Predicted Molecular Weight | ≈106.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 106.4 kDa |
| Cross-reactivity | Human, Rat |
| Uniprot ID | P29122 |
| Note | Gene ID: 5046; UniProt: P29122; Chromosome: 15q26.3; Predicted MW: 106.4 kDa |
| Function | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PCSK6 Polyclonal Antibody |
| Target | PCSK6 |
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