Rabbit Anti-S22AC/SLC22A12 Polyclonal Antibody
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产品编号
PAV3522
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别名
solute carrier family 22 member 12, OAT4L, RST, UAT, URAT1, hURAT1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | solute carrier family 22 member 12, OAT4L, RST, UAT, URAT1, hURAT1 |
| Catalog Number | PAV3522 |
| Product Description | Rabbit polyclonal antibody raised against human SLC22A12 (Solute carrier family 22 member 12). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SLC22A12 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转运蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| Immunogen | This antibody was raised against from part region of human SLC22A12 protein (UniProt: Q96S37) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 116085 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈59.6 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 59.6 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q96S37 |
| Note | Gene ID: 116085; UniProt: Q96S37; Chromosome: 11q13.1; Predicted MW: 59.6 kDa |
| Function | Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SLC22A12 Polyclonal Antibody |
| Target | SLC22A12 |
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