Rabbit Anti-METH/MTR Polyclonal Antibody
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产品编号
PAV2297
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别名
5-methyltetrahydrofolate-homocysteine methyltransferase, HMAG, MS, cblG
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | 5-methyltetrahydrofolate-homocysteine methyltransferase, HMAG, MS, cblG |
| Catalog Number | PAV2297 |
| Product Description | Rabbit polyclonal antibody raised against human MTR (Methionine synthase). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MTR |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 氧化还原酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] |
| Immunogen | This antibody was raised against from part region of human MTR protein (UniProt: Q99707) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 4548 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈140.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 140.5 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q99707 |
| Note | Gene ID: 4548; UniProt: Q99707; Chromosome: 1q43; Predicted MW: 140.5 kDa |
| Function | Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MTR Polyclonal Antibody |
| Target | MTR |
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