Rabbit Anti-MLL2/KMT2D Polyclonal Antibody
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产品编号
PAV2324
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别名
lysine methyltransferase 2D, AAD10, ALR, BCAHH, CAGL114, KABUK1, KMS, MLL2, MLL4
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | lysine methyltransferase 2D, AAD10, ALR, BCAHH, CAGL114, KABUK1, KMS, MLL2, MLL4 |
| Catalog Number | PAV2324 |
| Product Description | Rabbit polyclonal antibody raised against human KMT2D (Histone-lysine N-methyltransferase 2D). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: IHC-p. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | KMT2D |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 表观修饰酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010] |
| Immunogen | This antibody was raised against from part region of human KMT2D protein (UniProt: O14686) |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-200 |
| Gene ID | 8085 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈593.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 593.4 kDa |
| Cross-reactivity | Human |
| Uniprot ID | O14686 |
| Note | Gene ID: 8085; UniProt: O14686; Chromosome: 12q13.12; Predicted MW: 593.4 kDa |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human KMT2D Polyclonal Antibody |
| Target | KMT2D |
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