Rabbit Anti-RN220/RNF220 Polyclonal Antibody
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产品编号
PAV3420
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别名
ring finger protein 220, C1orf164, HLD23
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | ring finger protein 220, C1orf164, HLD23 |
| Catalog Number | PAV3420 |
| Product Description | Rabbit polyclonal antibody raised against human RNF220 (E3 ubiquitin-protein ligase RNF220). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RNF220 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables beta-catenin binding activity and ubiquitin protein ligase activity. Involved in positive regulation of canonical Wnt signaling pathway and protein polyubiquitination. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein monoubiquitination. Located in nuclear lamina and nucleoplasm. Part of protein-containing complex. Implicated in hypomyelinating leukodystrophy 23. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human RNF220 protein (UniProt: Q5VTB9) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 55182 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈62.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 62.8 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q5VTB9 |
| Note | Gene ID: 55182; UniProt: Q5VTB9; Chromosome: 1p34.1; Predicted MW: 62.8 kDa |
| Function | E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of multiple substrates including GRIA1, GRIA2, PHOX2A and PHOX2B, STAT1, STAT3 and SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling. Plays a critical role in the regulation of nuclear lamina. Modulates synaptic activity and brain functions by promoting degradation of AMPA receptor subunits GRIA1 and GRIA2. The RNF220/ZC4H2 complex monoubiquitinates PHOX2A and PHOX2B to enhance their DNA-binding ability and transactivity (By similarity). Promotes 'Lys-63'-linked polyubiquitination of Gli transcriptional activators and repressors, facilitating their nuclear export by CRM1 to fine-tune the sonic hedgehog/Gli signaling (By similarity). Regulates type I and type II interferon responses upon viral or bacterial infection by mediating 'Lys-63'-linked polyubiquitination of STAT1. Also regulates STAT3 phosphorylation, nuclear translocation, and transcriptional activity via ubiquitination. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RNF220 Polyclonal Antibody |
| Target | RNF220 |
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