H6N6 (A/duck/Eastern China/11/2009) HA1 Protein, His Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

H6N6 (A/duck/Eastern China/11/2009) HA1 Protein, His Tag

H6N6 (A/duck/Eastern China/11/2009) HA1 Protein, His Tag

产品编号

KMP4615

别名

甲型流感病毒H6N6血凝素蛋白1, H6N6 HA1, Hemagglutinin Protein, H6N6 HA1 Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	甲型流感病毒H6N6血凝素蛋白1, H6N6 HA1, Hemagglutinin Protein, H6N6 HA1 Protein
Catalog Number	KMP4615
Product Description	The H6N6 (A/duck/Eastern China/11/2009) HA1 Protein(KMP4615) is produced in HEK293 Cells. A DNA sequence encoding the Influenza A virus (A/duck/Eastern China/11/2009(H6N6)) hemagglutinin (AEF59343.1) (Met1-Arg344), termed as HA1, was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	H6N6 HA1
Species	H6N6
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, pH7.4
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-H6N6 HA1蛋白的流行趋势是什么？

H6亚型在中国东部家鸭中流行率高，其HA1变异监测对禽流感防控具有重要意义。
Q2-该蛋白是否适合结构生物学研究？

是的，高纯度（≥95%）和单分散性（DLS验证）满足X射线晶体学或冷冻电镜需求。
Q3-能否用于交叉保护抗体研究？

可测试H6N6 HA1抗体对其他H6亚型（如H6N1、H6N2）的中和活性，评估交叉反应性。
Q4-如何避免His标签的免疫干扰？

免疫动物时建议使用标签切除版本（需定制），或预吸附抗His标签抗体以减少背景。
Q5-是否提供天然折叠验证数据？

可提供圆二色光谱（CD）分析报告，确认其二级结构与天然构象一致。

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0