H12N5 (A/green-winged teal/ALB/199/1991) NA Protein_天津卡梅德科技发展有限公司

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H12N5 (A/green-winged teal/ALB/199/1991) NA Protein

H12N5 (A/green-winged teal/ALB/199/1991) NA Protein

产品编号

KMP4593

别名

甲型流感病毒H12N5神经氨酸酶, H12N5 NA, Neuraminidase Protein, H12N5 NA Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甲型流感病毒H12N5神经氨酸酶, H12N5 NA, Neuraminidase Protein, H12N5 NA Protein
Catalog Number	KMP4593
Product Description	The H12N5 (A/green-winged teal/ALB/199/1991) NA Protein(KMP4593) is produced in HEK293 Cells. A DNA sequence encoding Influenza virus A (A/green-winged teal/ALB/199/1991)(H12N5)) Neuraminidase (ABB88113.1) (Met1-Met473), termed as NA, was expressed.
Molecular Name	H12N5 NA
Species	H12N5
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 10% Glycerol, pH7.4
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-该NA蛋白未添加His标签，如何纯化？

通过离子交换层析和分子筛层析纯化，依赖其天然等电点和分子量差异。
Q2-绿翅鸭来源的H12N5有何研究价值？

H12亚型在禽类中罕见，其NA蛋白研究可补充流感病毒数据库的多样性信息。
Q3-能否用于抗体交叉反应性研究？

是的，可测试不同亚型（如H5N1、H7N9）抗血清的交叉中和活性。
Q4-蛋白的稳定性如何？

冻干后-20℃保存可稳定1年，复溶后4℃保存建议3天内使用。
Q5-是否支持定制化突变体构建？

可提供点突变（如耐药位点H274Y）服务，需提供具体突变位点信息。

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