H1N8 (A/Egyptian goose/South Africa/AI1448/2007) HA1 Protein, His Tag_天津卡梅德科技发展有限公司

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H1N8 (A/Egyptian goose/South Africa/AI1448/2007) HA1 Protein, His Tag

H1N8 (A/Egyptian goose/South Africa/AI1448/2007) HA1 Protein, His Tag

产品编号

KMP4530

别名

甲型流感病毒H1N8血凝素蛋白1, H1N8 HA1, Hemagglutinin Protein, H1N8 HA1 Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甲型流感病毒H1N8血凝素蛋白1, H1N8 HA1, Hemagglutinin Protein, H1N8 HA1 Protein
Catalog Number	KMP4530
Product Description	The H1N8 (A/Egyptian goose/South Africa/AI1448/2007) HA1 Protein(KMP4530) is produced in HEK293 Cells. A DNA sequence encoding the Influenza A virus (A/Egyptian goose/South Africa/AI1448/2007(H1N8)) hemagglutinin (Met1-Arg344), termed as HA1, was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	H1N8 HA1
Species	H1N8
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 10% Glycerol, 150mM NaCl, pH8.0
Background	Neuraminidases are enzymes that cleave sialic acid groups from glycoproteins. Influenza neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell. Influenza neuraminidase is composed of four identical subunits arranged in a square. It is normally attached to the virus surface through a long protein stalk. The active sites are in a deep depression on the upper surface. They bind to polysaccharide chains and clip off the sugars at the end. The surface of neuraminidase is decorated with several polysaccharide chains that are similar to the polysaccharide chains that decorate our cell surface proteins. Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of the influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme that facilitates virus release and efficient spread of the progeny virus from cell to cell. Influenza antibody and influenza antibodies are very important research tools for influenza diagnosis, influenza vaccine development, and anti-influenza virus therapy development. The monoclonal or polyclonal antibody can be raised with protein based antigen or peptide-based antigen. Antibodies raised with protein-based antigen could have better specificity and/or binding affinity than antibodies raised with peptide based antigen, but the cost associated with the recombinant protein antigen is usually higher. Anti-influenza virus hemagglutinin (HA) monoclonal antibody or polyclonal antibody can be used for ELISA assay, western blotting detection, Immunohistochemistry (IHC), flow cytometry, neutralization assay, hemagglutinin inhibition assay, and early diagnosis of influenza viral infection. Sino Biological has developed state-of-the-art monoclonal antibody development technology platforms: mouse monoclonal antibody and rabbit monoclonal antibody. Our rabbit monoclonal antibody platform is one of a kind and offers some unique advantages over mouse monoclonal antibodies, such as high affinity, low cross-reactivity with rabbit polyclonal antibodies.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-该HA1蛋白是否具有跨物种传播研究的价值？

是的，通过分析其与哺乳动物受体的结合偏好性（如α-2,6唾液酸），评估潜在人畜共患病风险。
Q2-如何验证蛋白的天然构象？

通过ELISA检测其与构象依赖性单克隆抗体的结合能力，确保RBD结构正确。
Q3-能否用于单克隆抗体的开发？

可以，作为免疫原或筛选抗原，用于小鼠或羊驼抗体库的构建与筛选。
Q4-批次间一致性如何控制？

每批次均通过SDS-PAGE、HPLC和血凝活性检测，确保差异≤5%。
Q5-是否支持冻干粉和液体两种形式？

支持，冻干粉可常温运输，液体需-80℃保存，用户可按实验需求选择。

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