HSV2 Vitamin D binding Protein(ECD), His Tag_天津卡梅德科技发展有限公司

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HSV2 Vitamin D binding Protein(ECD), His Tag

HSV2 Vitamin D binding Protein(ECD), His Tag

产品编号

KMP4838

别名

单纯疱疹病毒维生素D结合蛋白, HSV2 Vitamin D binding, GC Protein, HSV2 Vitamin D binding Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	单纯疱疹病毒维生素D结合蛋白, HSV2 Vitamin D binding, GC Protein, HSV2 Vitamin D binding Protein
Catalog Number	KMP4838
Product Description	The HSV2 Vitamin D binding Protein(KMP4838) is produced in Insect Cells. A DNA sequence encoding the HSV 2 (strain 333 (HSV2)) gC (translated amino acids of P06475) (Ser28-Gly447) was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	HSV2 Vitamin D binding
Species	HSV2
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-该蛋白在HSV-2感染中的功能是什么？

目前尚未明确HSV-2的“维生素D结合蛋白”在感染中的直接作用，可能是宿主蛋白的误命名或研究中的新发现靶点，需结合文献确认其具体功能。
Q2-ECD（胞外域）的设计有何意义？

去除跨膜区以提高可溶性，保留胞外功能域用于受体结合或免疫应答研究。
Q3-His标签是否影响蛋白功能验证？

标签位于C端，经ELISA或SPR验证不影响抗体结合活性，可通过镍柱高效纯化。
Q4-该蛋白能否用于宿主-病毒互作研究？

若为宿主蛋白，可用于研究HSV-2劫持维生素D代谢通路的机制；若为病毒蛋白，需明确其与宿主互作靶点。
Q5-储存条件如何优化？

建议-80℃保存，溶解后分装使用，避免反复冻融；缓冲液中含5%甘油增强稳定性。

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