HCoV-OC43 Spike S2 Protein(ECD), His Tag_天津卡梅德科技发展有限公司

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HCoV-OC43 Spike S2 Protein(ECD), His Tag

HCoV-OC43 Spike S2 Protein(ECD), His Tag

产品编号

KMP4828

别名

人类冠状病毒刺突蛋白S2, HCoV-OC43 Spike S2, S2 Protein, HCoV-OC43 Spike S2 Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	人类冠状病毒刺突蛋白S2, HCoV-OC43 Spike S2, S2 Protein, HCoV-OC43 Spike S2 Protein
Catalog Number	KMP4828
Product Description	The HCoV-OC43 (HCoV-OC43) Spike S2 Protein(KMP4828) is produced in Insect Cells. A DNA sequence encoding the human coronavirus (HCoV-OC43) Spike S2 Protein (AVR40344.1) (Ala766-Pro1304) was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	HCoV-OC43 Spike S2
Species	HCoV-OC43
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 300mM NaCl, 10% Glycerol, pH8.5
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-S2亚基的功能是什么？

S2介导病毒与宿主细胞膜融合，是广谱抗冠状病毒药物的潜在靶点。
Q2-OC43与其他β冠状病毒的S2保守性如何？

S2区域高度保守，研究其结构可为开发泛冠状病毒融合抑制剂提供依据。
Q3-能否用于脂质体融合实验？

是的，在酸性pH条件下可诱导脂质体膜融合，验证其功能活性。
Q4-蛋白的溶解性如何？

溶于含0.1% CHAPS的PBS缓冲液，浓度≥0.5 mg/mL，避免冻融。
Q5-是否支持结构解析合作？

可提供高纯度蛋白用于冷冻电镜或X射线晶体学研究（需签订协议）。

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