HBV (ayw/France/Tiollais/1979) Capsid Protein, His Tag_天津卡梅德科技发展有限公司

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HBV (ayw/France/Tiollais/1979) Capsid Protein, His Tag

HBV (ayw/France/Tiollais/1979) Capsid Protein, His Tag

产品编号

KMP4824

别名

乙型肝炎病毒衣壳蛋白, HBV Capsid, CP Protein, HBV Capsid Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	乙型肝炎病毒衣壳蛋白, HBV Capsid, CP Protein, HBV Capsid Protein
Catalog Number	KMP4824
Product Description	The HBV (ayw/France/Tiollais/1979) Capsid Protein(KMP4824) is produced in E. coli. A DNA sequence encoding the Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (P03146-1) (Met1-Val149) was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	HBV Capsid
Species	HBV
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-HBV衣壳蛋白的功能是什么？

由核心蛋白（Core）自组装成二十面体结构，包裹病毒基因组，是病毒复制和药物（如衣壳抑制剂）的作用靶点。
Q2-ayw亚型有何流行病学特征？

ayw是HBV基因型D的主要亚型，广泛分布于欧洲和北非，研究其衣壳蛋白可为区域疫苗设计提供参考。
Q3-该蛋白能否形成病毒样颗粒（VLPs）？

是的，在体外可自组装成直径约30 nm的颗粒，模拟天然衣壳结构。
Q4-如何检测衣壳蛋白的组装？

通过负染电镜观察颗粒形态，或动态光散射（DLS）检测粒径分布。
Q5-是否支持抗病毒药物筛选？

是的，可评估化合物对衣壳组装的干扰作用（如组装动力学分析）。

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