HeV (isolate Horse/Autralia/Hendra/1994) GP Protein, Fc Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

HeV (isolate Horse/Autralia/Hendra/1994) GP Protein, Fc Tag

HeV (isolate Horse/Autralia/Hendra/1994) GP Protein, Fc Tag

产品编号

KMP4815

别名

亨德拉病毒包膜糖蛋白, HeV GP, Glycoprotein, HeV GP Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	亨德拉病毒包膜糖蛋白, HeV GP, Glycoprotein, HeV GP Protein
Catalog Number	KMP4815
Product Description	The HeV (isolate Horse/Autralia/Hendra/1994) GP Protein(KMP4815) is produced in HEK293 Cells. A DNA sequence encoding glycoprotein G of the Hendra virus (isolate Horse/Autralia/Hendra/1994) (AAC83193.2) (Gln71-Ser604) was expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	HeV GP
Species	HeV
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 150mM NaCl, 5% Glycerol, pH7.0
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-HeV GP蛋白的功能是什么？

GP蛋白介导病毒与宿主细胞受体（EFNB2）结合，并触发膜融合，是中和抗体的主要靶点。
Q2-亨德拉病毒的人畜共患风险如何？

HeV可通过蝙蝠-马-人传播，致死率高，研究GP蛋白有助于开发治疗性抗体（如m102.4）。
Q3-Fc标签如何增强GP蛋白的应用？

Fc标签延长蛋白半衰期，并允许通过Protein A/G纯化，还可用于抗体依赖性细胞毒性（ADCC）研究。
Q4-该蛋白是否形成三聚体？

经凝胶过滤和电镜验证，GP以天然三聚体形式存在，模拟病毒表面构象。
Q5-能否用于ELISA检测马血清抗体？

是的，作为包被抗原时，灵敏度高，可检测马匹感染后的特异性IgG。

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0