H10N7 (A/blue-winged teal/Louisiana/Sg-00073/2007) HA Protein, His Tag_天津卡梅德科技发展有限公司

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H10N7 (A/blue-winged teal/Louisiana/Sg-00073/2007) HA Protein, His Tag

H10N7 (A/blue-winged teal/Louisiana/Sg-00073/2007) HA Protein, His Tag

产品编号

KMP4616

别名

甲型流感病毒H10N7血凝素蛋白, H10N7 HA, Hemagglutinin Protein, H10N7 HA Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甲型流感病毒H10N7血凝素蛋白, H10N7 HA, Hemagglutinin Protein, H10N7 HA Protein
Catalog Number	KMP4616
Product Description	The H10N7 (A/blue-winged teal/Louisiana/Sg-00073/2007) HA Protein(KMP4616) is produced in Insect Cells. A DNA sequence encoding the Influenza A virus (A/blue-winged teal/Louisiana/Sg-00073/2007(H10N7)) hemagglutinin (ADH96304.1) (Met1-Val525), termed as HA, was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	H10N7 HA
Species	H10N7
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-蓝翅鸭作为宿主的研究价值是什么？

蓝翅鸭是北美候鸟，其携带的H10N7病毒可能通过迁徙路线传播，研究HA可追踪病毒地理扩散路径。
Q2-该HA蛋白的受体结合特异性如何？

偏好结合禽源α-2,3唾液酸受体，与人源α-2,6受体结合能力较低（需实验验证）。
Q3-能否用于黏膜疫苗研究？

需与佐剂（如CTB或TLR激动剂）配伍，通过滴鼻免疫评估黏膜IgA应答。
Q4-是否提供生物安全等级说明？

该毒株为低致病性（需确认来源数据），实验操作建议在BSL-2实验室进行。
Q5-蛋白的表达量和批次一致性如何？

每批产量≥5 mg/L，SDS-PAGE和Western Blot验证批间差异<15%。

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