H18N11 (A/flat-faced bat/Peru/033/2010) HA1 Protein, His Tag_天津卡梅德科技发展有限公司

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H18N11 (A/flat-faced bat/Peru/033/2010) HA1 Protein, His Tag

H18N11 (A/flat-faced bat/Peru/033/2010) HA1 Protein, His Tag

产品编号

KMP4595

别名

甲型流感病毒H18N11血凝素蛋白1, H18N11 HA1, Hemagglutinin Protein, H18N11 HA1 Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甲型流感病毒H18N11血凝素蛋白1, H18N11 HA1, Hemagglutinin Protein, H18N11 HA1 Protein
Catalog Number	KMP4595
Product Description	The H18N11 (A/flat-faced bat/Peru/033/2010) HA1 Protein(KMP4595) is produced in HEK293 Cells. A DNA sequence encoding the Influenza A virus (A/flat-faced bat/Peru/033/2010 (H18N11)) hemagglutinin (AGX84934.1) (Met1-Arg339), termed as HA1, was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	H18N11 HA1
Species	H18N11
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 10% Glycerol, pH8.0
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-HA1与全长HA蛋白的功能差异是什么？

HA1含受体结合域（RBD），但不含HA2的融合肽，因此仅用于结合研究而非膜融合分析。
Q2-该蛋白能否用于受体结合谱分析？

是的，可通过糖芯片技术检测其对不同聚糖的结合特异性。
Q3-是否提供结构解析数据？

可提供预测的3D结构模型（基于AlphaFold），实验结构需合作研究。
Q4-如何避免蛋白降解？

添加1 mM EDTA和蛋白酶抑制剂，建议分装后-80℃保存。
Q5-是否适用于噬菌体展示文库筛选？

是的，可固相化HA1筛选特异性结合多肽或抗体片段。

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