H18N11 (A/flat-faced bat/Peru/033/2010) HA Protein, His Tag_天津卡梅德科技发展有限公司

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H18N11 (A/flat-faced bat/Peru/033/2010) HA Protein, His Tag

H18N11 (A/flat-faced bat/Peru/033/2010) HA Protein, His Tag

产品编号

KMP4594

别名

甲型流感病毒H18N11血凝素蛋白, H18N11 HA, Hemagglutinin Protein, H18N11 HA Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甲型流感病毒H18N11血凝素蛋白, H18N11 HA, Hemagglutinin Protein, H18N11 HA Protein
Catalog Number	KMP4594
Product Description	The H18N11 (A/flat-faced bat/Peru/033/2010) HA Protein(KMP4594) is produced in Insect Cells. A DNA sequence encoding the Influenza A virus (A/flat-faced bat/Peru/033/2010(H18N11)) hemagglutinin (AGX84934.1) (Met1-Asp513), termed as HA, was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	H18N11 HA
Species	H18N11
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 10% Glycerol, pH8.0
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-蝙蝠来源的H18N11 HA蛋白有何特殊性？

蝙蝠是新型流感病毒的潜在宿主，其HA结构与禽/人流感病毒差异显著，为跨物种传播机制研究提供独特模型。
Q2-该HA蛋白能否结合传统唾液酸受体？

初步研究表明其可能通过非唾液酸受体机制入侵细胞，需进一步验证。
Q3-是否适用于假病毒系统？

是的，可与慢病毒载体组装假病毒，用于中和实验或宿主嗜性研究。
Q4-该蛋白的表达系统是什么？

采用Expi293F哺乳动物细胞表达，确保复杂糖基化修饰。
Q5-是否有已知的交叉反应抗体？

目前未发现与H1-H17亚型HA抗体的交叉反应，提示其抗原独特性。

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