H15N2 (A/Australian shelduck/Western Australia/1756/1983) HA Protein, His Tag_天津卡梅德科技发展有限公司

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H15N2 (A/Australian shelduck/Western Australia/1756/1983) HA Protein, His Tag

H15N2 (A/Australian shelduck/Western Australia/1756/1983) HA Protein, His Tag

产品编号

KMP4577

别名

甲型流感病毒H15N2血凝素蛋白, H15N2 HA, Hemagglutinin Protein, H15N2 HA Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甲型流感病毒H15N2血凝素蛋白, H15N2 HA, Hemagglutinin Protein, H15N2 HA Protein
Catalog Number	KMP4577
Product Description	The H15N2 (A/Australian shelduck/Western Australia/1756/1983) HA Protein(KMP4577) is produced in Insect Cells. A DNA sequence encoding the Influenza A virus (A/Australian shelduck/Western Australia/1756/1983(H15N2)) hemagglutinin (ABB90704.1) (Met1-Val534) was expressed with a C-terminal polyhistidine tag.
Molecular Name	H15N2 HA
Species	H15N2
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-全长HA蛋白是否包含跨膜结构域？

本产品为可溶性截短版本，去除跨膜区，保留胞外域（HA1+HA2）以增强溶解性。
Q2-该蛋白能否形成天然三聚体结构？

经凝胶过滤层析验证，主要以三聚体形式存在，模拟病毒表面天然构象。
Q3-适用于哪些功能研究？

病毒入侵机制分析、广谱中和抗体筛选及疫苗抗原设计。
Q4-是否提供受体结合动力学数据？

可提供表面等离子共振（SPR）测定的亲和力常数（KD值，需额外订购）。
Q5-运输过程中如何保证蛋白活性？

干冰运输，确保全程-80℃保存，到货后建议立即分装冻存。

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