H14N5 (A/mallard/Astrakhan/263/1982) HA1 Protein, His Tag_天津卡梅德科技发展有限公司

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H14N5 (A/mallard/Astrakhan/263/1982) HA1 Protein, His Tag

H14N5 (A/mallard/Astrakhan/263/1982) HA1 Protein, His Tag

产品编号

KMP4576

别名

甲型流感病毒H14N5血凝素蛋白1, H14N5 HA1, Hemagglutinin Protein, H14N5 HA1 Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甲型流感病毒H14N5血凝素蛋白1, H14N5 HA1, Hemagglutinin Protein, H14N5 HA1 Protein
Catalog Number	KMP4576
Product Description	The H14N5 (A/mallard/Astrakhan/263/1982) HA1 Protein(KMP4576) is produced in HEK293 Cells. A DNA sequence encoding the Influenza A virus (A/mallard/Astrakhan/263/1982(H14N5)) hemagglutinin (P26136) (Met1-Lys342), termed as HA1, was expressed with a C-terminal polyhistidine tag.
Molecular Name	H14N5 HA1
Species	H14N5
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-H14亚型HA1的独特功能是什么？

H14属于罕见亚型，其HA1受体结合特性可能反映禽流感病毒在野鸭中的独特进化路径。
Q2-该蛋白的冻干保护剂是什么？

含海藻糖和甘露醇，复溶后稳定性高，可直接用于实验。
Q3-能否用于单颗粒冷冻电镜研究？

需验证蛋白单分散性，建议超速离心后使用，可提供动态光散射（DLS）数据。
Q4-是否支持大规模生产？

可提供毫克至克级定制生产服务，交货周期需具体协商。
Q5-该蛋白的热稳定性如何？

37℃孵育1小时活性保留>80%，建议短期实验在4℃下进行。

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