H5N8 (A/turkey/Ireland/1378/1983) HA1 Protein, His Tag_天津卡梅德科技发展有限公司

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H5N8 (A/turkey/Ireland/1378/1983) HA1 Protein, His Tag

H5N8 (A/turkey/Ireland/1378/1983) HA1 Protein, His Tag

产品编号

KMP4554

别名

甲型流感病毒H5N8血凝素蛋白1, H5N8 HA1, Hemagglutinin Protein, H5N8 HA1 Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甲型流感病毒H5N8血凝素蛋白1, H5N8 HA1, Hemagglutinin Protein, H5N8 HA1 Protein
Catalog Number	KMP4554
Product Description	The H5N8 (A/turkey/Ireland/1378/1983) HA1 Protein(KMP4554) is produced in HEK293 Cells. A DNA sequence encoding the Influenza A virus (A/turkey/Ireland/1378/1983(H5N8)) hemagglutinin (P11135) (Met1-Arg339), termed as HA1, was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	H5N8 HA1
Species	H5N8
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris, 0.1% Tween, pH9.0
Background	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-HA1亚基是否包含完整的受体结合域（RBD）？

是的，HA1涵盖完整的RBD，用于研究病毒与宿主受体的相互作用及抗体中和机制。
Q2-能否用于广谱中和抗体筛选？

可以，与其他H5亚型（如H5N1、H5N6）HA1对比，评估抗体的交叉保护能力。
Q3-如何验证蛋白的正确折叠？

通过圆二色谱（CD）分析二级结构，并结合ELISA验证其与中和抗体的结合能力。
Q4-是否提供糖基化分析服务？

支持，通过质谱鉴定糖基化位点，并提供糖链修饰模式报告。
Q5-运输条件是什么？

液体需干冰运输，冻干粉可常温运输，复溶后建议分装保存于-80℃。

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